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MRI volumetric and 31 P MRS metabolic correlates of caudate nucleus in antipsychotic‐naïve schizophrenia
Author(s) -
Jayakumar P. N.,
Venkatasubramanian G.,
Keshavan M. S.,
Srinivas J. S.,
Gangadhar B. N.
Publication year - 2006
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.2006.00836.x
Subject(s) - caudate nucleus , phosphocreatine , medicine , schizophrenia (object oriented programming) , endocrinology , antipsychotic , basal ganglia , magnetic resonance imaging , psychosis , psychology , nuclear medicine , chemistry , psychiatry , central nervous system , radiology , energy metabolism
Objective: To examine the volumetric and metabolic correlates of caudate nucleus in antipsychotic‐naïve schizophrenia patients in comparison with healthy controls. Method: Twelve antipsychotic‐naïve schizophrenia patients and 13 healthy controls underwent 31 P magnetic resonance spectroscopy of basal ganglia. Magnetic resonance imaging volume of caudate nuclei was measured using scion image software. Results: Patients had significantly smaller caudate volume than healthy controls. Phosphocreatine (PCr)/total phosphorous and PCr/total adenosine tri‐phosphate ratios of both caudate nuclei were significantly lower in patients than controls. Significant negative correlation was found between the left caudate volume and left PCr/total phosphorus ratio in the patients. Age at onset of psychosis had i) significant negative correlation with right and left caudate volumes and ii) significant positive correlation with left PCr/total phosphorus ratio. Conclusion: The metabolic and volumetric abnormalities of caudate nucleus in antipsychotic‐naïve schizophrenia patients support neurodevelopmental etiopathogenesis.