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Altered omega‐3 polyunsaturated fatty acid status in depressed post‐myocardial infarction patients
Author(s) -
Schins A.,
Crijns H. J.,
Brummer R.J. M.,
Wichers M.,
Lousberg R.,
Celis S.,
Honig A.
Publication year - 2007
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.2006.00830.x
Subject(s) - medicine , polyunsaturated fatty acid , arachidonic acid , myocardial infarction , c reactive protein , eicosapentaenoic acid , depression (economics) , inflammation , endocrinology , fatty acid , gastroenterology , chemistry , biochemistry , enzyme , economics , macroeconomics
Objective: Lower levels of long‐chain omega‐3 polyunsaturated fatty acids (n‐3 LCPUFAs) and increased inflammation have been associated with both depressive disorder and myocardial infarction (MI). The present study investigated whether patients who develop depression post‐MI, have higher arachidonic acid/eicosapentanoic acid (AA/EPA) ratios than non‐depressed post‐MI patients and whether depressed post‐MI patients have signs of increased inflammation as measured by C‐reactive protein (CRP). Method: Serum AA/EPA ratio and plasma CRP levels were quantified in 50 post‐MI patients, of which 29 were depressed and 21 non‐depressed. Results: Compared with the non‐depressed group, depressed post‐MI patients had significantly higher AA/EPA ratios. No significant difference was observed in CRP levels. Conclusion: Depressed post‐MI patients had lower levels of n‐3 LCPUFAs as measured by mean AA/EPA ratio and no signs of increased inflammation as determined by CRP levels.