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The effect of temperament and character on response to selective serotonin reuptake inhibitors in panic disorder
Author(s) -
Marchesi C.,
Cantoni A.,
Fontò S.,
Giannelli M. R.,
Maggini C.
Publication year - 2006
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.2006.00772.x
Subject(s) - temperament and character inventory , harm avoidance , cooperativeness , temperament , reward dependence , persistence (discontinuity) , confounding , psychology , panic , panic disorder , clinical psychology , pharmacotherapy , medicine , psychiatry , personality , anxiety , social psychology , geotechnical engineering , engineering
Objective: In this prospective study, temperament and character were evaluated in patients with panic disorder (PD), before 1 year of medication therapy, to verify whether these factors influenced the outcome of treatment. Method: Seventy‐one PD patients were evaluated with the SCID‐IV, the Temperament and Character Inventory (TCI), the SCL‐90, the Ham‐A and the Ham‐D. Patients were treated with pharmacotherapy and were evaluated monthly over 1 year. Results: Before treatment, non‐remitted patients showed higher levels of harm avoidance (HA) and lower levels of persistence (P), self‐directedness (SD) and cooperativeness (C), whereas remitted patients showed only higher levels of HA. After controlling the effect of the confounding variables, the likelihood to achieve remission was positively related to SD score (OR = 1.12; P = 0.002), particularly ‘self‐acceptance’ SD dimension (OR = 1.30; P = 0.02). Conclusions: Our data suggest that in PD: i) the evaluation of personality, using the Cloninger's model, confirms the presence of personality pathology as one predictor of non‐response to treatment; ii) in patients with low SD a combination of medication and cognitive‐behaviour therapy should be the most effective treatment.