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Association between apolipoprotein E ɛ 4 allele and apathy in probable Alzheimer's disease
Author(s) -
Monastero R.,
Mariani E.,
Camarda C.,
Ingegni T.,
Averna M. R.,
Senin U.,
Camarda R.,
Mecocci P.
Publication year - 2006
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.2005.00597.x
Subject(s) - apathy , apolipoprotein e , allele , genotype , medicine , logistic regression , alzheimer's disease , disease , psychology , association (psychology) , allele frequency , psychiatry , oncology , gastroenterology , genetics , biology , gene , psychotherapist
Objective: There have been inconclusive results to date on the association between the Apolipoprotein E (ApoE) genotype and neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD). We investigated whether ApoE ɛ 4 allele is associated with NPS in probable AD. Method: Data for 197 subjects with probable AD were analysed. The Neuropsychiatric Inventory was used to evaluate the frequency and severity of NPS. Multiple logistic regression models were used to test the association between ApoE genotype and NPS in AD. Results: The ApoE ɛ 3/3 genotype was present in 52.3%, ɛ 3/4 in 44.1%, and ɛ 4/4 in 3.6% of patients. ApoE ɛ 4 carriers showed a higher frequency of apathy than non‐carriers. After multiple adjustments, the ApoE ɛ 4 allele was significantly associated with apathy. Conclusion: Our results suggest a relationship between the ApoE ɛ 4 allele and apathy in patients with AD.