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Atypical neuroleptic malignant syndrome caused by olanzapine
Author(s) -
Nielsen J.,
Bruhn A. M.
Publication year - 2005
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.2005.00578.x
Subject(s) - neuroleptic malignant syndrome , olanzapine , discontinuation , delirium , hyperthermia , psychopathology , medicine , anesthesia , psychology , psychiatry , schizophrenia (object oriented programming)
Objective: Neuroleptic malignant syndrome (NMS) is a rare syndrome with four main symptoms: rigidity, hyperthermia, altered mental status and autonomic instability. We report a patient with an atypical manifestation of NMS. Method: A single case was reported. Results: A patient with pneumonia developed delirium and was treated with olanzapine and developed a NMS with fluctuating hyperthermia and autonomic instability during a month. Only slight rigidity was present. Creatine kinase was not elevated. The patient was severely agitated and manic. After discontinuation of olanzapine the patient showed no psychopathology or hyperthermia. Conclusion: NMS should be considered when patients treated with antipsychotics develop one or more symptoms of NMS.