Premium
Randomized double blind comparison of olanzapine vs. clozapine on subjective well‐being and clinical outcome in patients with schizophrenia
Author(s) -
Naber D.,
Riedel M.,
Klimke A.,
Vorbach E.U.,
Lambert M.,
Kühn K.U.,
Bender S.,
Bandelow B.,
Lemmer W.,
Moritz S.,
Dittmann R. W.
Publication year - 2005
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.2004.00486.x
Subject(s) - olanzapine , clinical global impression , clozapine , schizophrenia (object oriented programming) , randomized controlled trial , psychology , medicine , quality of life (healthcare) , psychiatry , positive and negative syndrome scale , clinical trial , psychosis , placebo , psychotherapist , alternative medicine , pathology
Objective: This randomized double‐blind multicenter trial evaluated the effects of olanzapine vs. clozapine on subjective well‐being, quality of life (QOL) and clinical outcome. Method: The primary objective was to demonstrate non‐inferiority of olanzapine, mean dosage 16.2 ± 4.8 (5–25 mg/day) vs. clozapine, mean dosage 209 ± 91 (100–400 mg/day) regarding improvement on the ‘Subjective Well‐Being under Neuroleptic Treatment’ (SWN) Scale after 26 treatment weeks in 114 patients with schizophrenia. Secondary outcome parameters included: Munich QOL Dimension List (MLDL), Positive and Negative Symptom Scale (PANSS), Clinical Global Impression (CGI). Results: SWN scores improved significantly in both groups, olanzapine was non‐inferior to clozapine (group difference 3.2 points in favor of olanzapine; 95% CI: 4.2;10.5). MLDL‐satisfaction, PANSS and CGI‐S improved similarly, olanzapine yielded a higher CGI Therapeutic Index. Individual SWN and PANSS changes correlated only moderately ( r = −0.45). Conclusion: Olanzapine was non‐inferior to clozapine. The lack of a marked correlation between PANSS and SWN improvements indicates that patients and psychiatrists perceive treatment differently.