Premium
Craniofacial dysmorphology in Swedish schizophrenia patients
Author(s) -
Kelly B. D.,
Lane A.,
Agartz I.,
Henriksson K. M.,
McNeil T. F.
Publication year - 2005
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.2004.00473.x
Subject(s) - craniofacial , schizophrenia (object oriented programming) , psychology , medicine , psychiatry , clinical psychology
Objective: To perform detailed assessments of craniofacial dysmorphology in individuals with schizophrenia and controls in Sweden, in order to further elucidate the neurodevelopmental origins of schizophrenia. Method: We performed detailed, anthropometric assessments of craniofacial dysmorphology in male patients with schizophrenia ( n = 24), healthy controls ( n = 16), and patients’ siblings with schizophrenia ( n = 2) in Sweden, while remaining as blind as possible to schizophrenia/control status. Results: Individuals with schizophrenia evidenced significantly more craniofacial dysmorphology than controls, especially in the ears and mouth. At a group level, there was a dose–response type relationship between total dysmorphology score and patient/control status. Conclusion: The consistency of results across multiple studies supports the hypothesis that individuals with schizophrenia have increased rates of prenatal developmental disturbances. The presence of a dose–response type relationship between total dysmorphology score and patient/control status supports the importance of neurodevelopmental disturbance as a contributory cause of schizophrenia.