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The allele interaction between apolipoprotein ɛ 2 and ɛ 4 in Taiwanese Alzheimer's disease patients
Author(s) -
Lung F.W.,
Yen Y.C.,
Chou L.J.,
Hong C.J.,
Wu C.K.
Publication year - 2005
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.2004.00394.x
Subject(s) - allele , apolipoprotein e , genotype , allele frequency , alzheimer's disease , disease , medicine , degenerative disease , genetics , biology , gene
Objective: This study aimed to determine the impact of the present of apolipoprotein ɛ (Apo ɛ ) 2 on the relationship between Apo ɛ 4 and Alzheimer's disease (AD). Method: We examined ApoE genotypes in 428 Taiwanese patients with AD and 807 controls; all participants were older than 65 years. Results: The allele frequency of Apo ɛ 4 was greater in AD patients than controls, but significantly lower than in Caucasians. The presence of an ɛ 2 allele alone was not associated with lower risk for AD, but the presence of an ɛ 2 allele was associated with an ɛ 4 allele frequency similar to that of controls. Conclusion: The low allele frequency of ɛ 4 in persons with an ɛ 2 allele suggests that this may be part of the protective effect of ɛ 2 against AD.