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Regional cerebral blood flow and depersonalization after tetrahydrocannabinol adrninistration
Author(s) -
Mathew R. J.,
Wilson W. H.,
Chiu N.Y.,
Turkington T. G.,
Degrado T. R.,
Coleman R. E.
Publication year - 1999
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1999.tb10916.x
Subject(s) - depersonalization , cerebral blood flow , psychology , positron emission tomography , medicine , anesthesia , nuclear medicine , neuroscience , clinical psychology , emotional exhaustion , burnout
Mathew RJ, Wilson WH, Chiu NY, Turkington TG, Degrado TR, Coleman RE. Regional cerebral blood flow and depersonalization after tetrahydrocannabinol administration. Acta Psychiatr Scand 1999: 100 : 67–75. © Munksgaard 1999. Objective: The aim of this study was to examine the relationship between depersonalization induced by tetrahydrocannabinol (THC), and regional brain activation. Method Cerebral blood flow (CBF) was measured by means of positron emission tomography (PET) in 59 normal right‐handed volunteers before and following intravenous infusions of THC. Results: After THC, CBF showed a global increase which was more marked in the right hemisphere, frontal lobes and anterior cingulate. Conclusion: Regression analyses showed positive correlations between the right frontal and anterior cingulate and depersonalization.