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Mitral valve prolapse and autonomic function in panic disorder
Author(s) -
Hamada T.,
Koshino Y.,
Misawa T.,
Isaki K.,
Gejyo F.
Publication year - 1998
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1998.tb09976.x
Subject(s) - mitral valve prolapse , panic disorder , panic , medicine , depression (economics) , cardiology , autonomic nervous system , mitral valve , parasympathetic nervous system , incidence (geometry) , heart rate , psychiatry , anxiety , blood pressure , physics , optics , economics , macroeconomics
We investigated the significance of mitral valve prolapse (MVP) and autonomic function in 121 patients diagnosed with panic disorder (PD). The incidence of MVP was higher in these patients (32.2%) than in the healthy controls (16.7%), but the difference was not significant. In the group with PD accompanied by depression, the MVP rate was 58.1%, significantly higher than the value of 25.7% observed in the PD patients without depression. The severity of MVP was mild; nearly all of the cases were silent, without cardiac murmur, and there was no problem with the left ventricular function. The coefficient of variation for R‐R intervals on electrocardiograms (CV R‐R) was smaller in patients with PD than in healthy controls. The CV R‐R of PD patients was significantly lower in the group with MVP than in the group without MVP, suggesting a strong association with the parasympathetic nervous system. Since the CV R‐R tended to decrease in the presence of depression, involvement of the parasympathetic nervous system was inferred.