Premium
Caudate nucleus area in drug‐induced parkinsonism
Author(s) -
Brown K. W.,
Wardlaw J. M.,
White T.,
Walker N.
Publication year - 1996
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1996.tb09871.x
Subject(s) - caudate nucleus , parkinsonism , antipsychotic , psychology , antipsychotic drug , striatum , schizophrenia (object oriented programming) , neuroscience , medicine , psychiatry , dopamine , disease
This study examined caudate nuclei areas in 10 schizophrenic subjects with and 25 schizophrenic subjects without parkinsonian symptoms. The subjects with parkinsonian symptoms were found to have statistically significantly smaller right caudate nuclei and a trend towards smaller left caudates. Cortical measurements did not differ between the groups. These results are consistent with the suggestion that antipsychotic drugs exert some neurotoxic effects, but should be viewed as preliminary and require replication.