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Classification of patients with affective disorders using platelet monoamine oxidase activity, serum melatonin and post‐dexamethasone Cortisol
Author(s) -
Wahlund B.,
Sääf J.,
Wetterberg L.
Publication year - 1995
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1995.tb09788.x
Subject(s) - melatonin , medicine , monoamine oxidase , endocrinology , neuroticism , hydrocortisone , depression (economics) , psychology , dexamethasone , psychosis , monoamine neurotransmitter , dexamethasone suppression test , psychiatry , serotonin , personality , chemistry , enzyme , economics , macroeconomics , social psychology , biochemistry , receptor
Platelet monoamine oxidase activity (MAO), melatonin and Cortisol post‐dexamethasone suppression test (DST) were examined in 28 patients with major affective disorder and in 20 controls. MAO activity was lower and Cortisol post‐dexamethasone was higher in depressed patients. Platelet MAO activity and Cortisol in depressed and controls yielded high sensitivity (90%) and specificity (89%). The patients were re‐examined after 10 years and categorized into affective psychosis or neurotic depression (ICD‐9). Multidimensional analysis identified one subgroup coinciding in 92% with affective psychosis and another subgroup coinciding in 87% with neurotic depression. Combination of MAO, melatonin and post‐DST Cortisol may be useful in the diagnosis of subgroups of depressed patients and in choice of therapy.