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Lack of association of schizophrenia with the neurotrophin‐3 gene locus
Author(s) -
Nimgaonkar V. L.,
Zhang X. R.,
Brar J. S.,
DeLeo M.,
Ganguli R.
Publication year - 1995
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1995.tb09614.x
Subject(s) - locus (genetics) , psychosis , genetic association , neurotrophin 3 , schizophrenia (object oriented programming) , neurotrophin , association (psychology) , genetics , ethnic group , gene , allele , psychology , medicine , psychiatry , biology , genotype , neurotrophic factors , single nucleotide polymorphism , brain derived neurotrophic factor , receptor , psychotherapist , sociology , anthropology
A case‐control association study was conducted among patients with schizophrenia (DSM‐III‐R, n = 141) and unaffected controls ( n = 177) of Caucasain and African‐American ethnicity. No significant differences in the distribution of a dinucleotide repeat polymorphism in the neurotrophin‐3 (NT‐3) gene were noted between the two groups. This study does not support an association between schizophrenia and the NT‐3 gene locus in a United States cohort.