Premium
Antideficit properties of neuroleptics
Author(s) -
Colonna L.
Publication year - 1994
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1994.tb05838.x
Subject(s) - amisulpride , period (music) , schizophrenia (object oriented programming) , stimulant , psychology , psychiatry , medicine , pharmacology , antipsychotic , philosophy , aesthetics
The antidelusion effect, in the antiproductive sense of the term, represents the essential property of neuroleptics in research and publications in the United States. In France and in other European countries, however. a particular effect was observed early on that received various labels: disinhibitor, stimulant, antiautistic and anti‐deficit, and that involved the beneficial action of certain neuroleptics on the negative symptoms of schizophrenia. The first period, ranging from 1952 to 1976, was characterized by a number of clinical observations and attempts at classification. In the second period, 1976 to 1984, much work was done in pharmacology and biochemistry. In the third period, 1984 to 1989, double‐blind studies confirmed, among others, the disinhibiting effect, first of low doses of sulpride and then of amisulpride.