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The tolerabilitv and efficacv of the atypical neuroleptic remoxipride cokpared with clozapine and haloperidol in acute schizophrenia
Author(s) -
Klieser E.,
Strauss W. H.,
Lemmer W.
Publication year - 1994
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1994.tb05836.x
Subject(s) - clozapine , haloperidol , psychopathology , schizophrenia (object oriented programming) , psychology , clinical global impression , brief psychiatric rating scale , psychosis , psychiatry , rating scale , medicine , dopamine , developmental psychology , alternative medicine , pathology , neuroscience , placebo
Remoxipride and clozapine are new neuroleptics that are thought to be superior to the substances in use by their efficacy and tolerance. At the University Clinic of Psychiatry in Dusseldorf a double‐blind study with 54 patients diagnosed as schizophrenic in accordance with DSM‐III was conducted to record the influence of the neuroleptics remoxipride, clozapine and haloperidol on schizophrenic psychosis. The schizophrenic symptoms were rated by the AMDP‐system (Arbeitsgemeinschaft fur Methodik und Dokumentation in der Psychiatrie), Brief Psychiatric Rating Scale and the Clinical Global Impression on days 0, 7, 14, 21 and 28 of treatment to evaluate the degree of change in psychopathology. The tolerance of the neuroleptic treatment was checked by the doctor's overall impression and the somatic findings of the AMDP‐system. All 3 neuroleptics reduced the schizophrenic symptoms to a similar degree but showed differentiation as to their side effects.