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Uptake of 99m Tc‐exametazime shown by single photon emission computerized tomography in obsessive‐compulsive disorder compared with major depression and normal controls
Author(s) -
Edmonstone Y.,
Austin M.P.,
Prentice N.,
Dougall N.,
Freeman C. P. L.,
Ebmeier K. P.,
Goodwin G. M.
Publication year - 1994
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1994.tb01597.x
Subject(s) - basal ganglia , basal (medicine) , depression (economics) , single photon emission computed tomography , emission computed tomography , psychology , nuclear medicine , anxiety , cortex (anatomy) , positron emission tomography , neuroscience , psychiatry , medicine , central nervous system , insulin , economics , macroeconomics
Twelve patients with obsessive‐compulsive disorder (OCD) were investigated at rest using single photon emission computerized tomography with 99m Tc‐exametazime. The uptake of 99m Tc‐exametazime was expressed relative to calcarine/occipital cortex. Patients were matched for drug treatment with 12 patients with a major depressive episode and the patient groups were compared with a control group. Significant bilateral decreases in tracer uptake were confined to basal ganglia in the OCD group. There was a paradoxical positive correlation between anxiety ratings and tracer uptake to basal ganglia in the OCD group. The findings confirm that the functional topography of OCD implicates altered function in the basal ganglia.