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Prophylactic effect of mianserin on recurrent depression
Author(s) -
Kishimoto A.,
Mizukawa R.,
Matsuzaki F.,
Hazama H.,
Kamase H.,
Tanaka K.,
Kunimoto N.
Publication year - 1994
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1994.tb01484.x
Subject(s) - mianserin , depression (economics) , medicine , psychiatry , psychology , antidepressant , anxiety , keynesian economics , economics
The prophylactic effect of mianserin on recurrent depression was studied in a double‐blind comparison with an inactive placebo by analyzing the recurrence rate and the number of depressive episodes in 9 mianserin‐treated (daily dose 20–60 mg) and 13 placebo‐treated patients. The selected patients were those who had a higher incidence of recurrence (more than 2 depressive episodes during the 2 years preceding the study). During the 18‐month study period, 4 of 9 mianserin‐treated patients and all 13 placebo‐treated patients had recurrences. The ratio between patients with recurrence and total patients (recurrence ratio) was lower in the mianserin‐treated group throughout the study, and the intergroup difference from the 3rd to the 18th month was significant. In the mianserin‐treated group, the frequency of episode recurrence during the study period was significantly lower and the total duration of episodes was significantly shorter than those in the placebo‐treated group. The treatments did not differ significantly in safety. These results clearly indicate that mianserin is effective in the prophylaxis of recurrent depressive episodes.