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Circadian variation in plasma 5‐hydroxyindoleacetic acid level during and after alcohol withdrawal: phase advances in alcoholic patients compared with normal subjects
Author(s) -
Sano H.,
Suzuki Y.,
Yazaki R.,
Tamefusa K.,
Ohara K.,
Yokoyama T.,
Miyasato K.,
Ohara K.
Publication year - 1993
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1993.tb03374.x
Subject(s) - delirium tremens , serotonergic , circadian rhythm , 5 hydroxyindoleacetic acid , medicine , alcohol , plasma levels , endocrinology , anesthesia , psychology , serotonin , chemistry , biochemistry , receptor
Alcohol withdrawal symptoms in 19 male alcoholics were objectively evaluated and classified and circadian variation in their plasma 5‐hydroxyindoleacetic acid (5‐HIAA) concentrations was determined at 3 different intervals after cessation of drinking. Circadian variations in plasma 5‐HIAA level exhibited phase advances in alcoholic patients compared with normal controls and were different depending on the severity of alcohol withdrawal symptoms. Plasma 5‐HIAA in patients with delirium tremens showed significantly higher levels during the abstention period, possibly suggesting peculiarity in their serotonergic metabolism.