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Effect of lithium dosing schedule on urinary output
Author(s) -
O'Donovan C.,
Hawkes J.,
Bowen R.
Publication year - 1993
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1993.tb03336.x
Subject(s) - dosing , lithium (medication) , schedule , urinary system , medicine , intensive care medicine , psychology , computer science , operating system
Lithium has been reported to induce polyuria in up to 35% of patients receiving it. It has been suggested that polyuria may be reduced by using single rather than multiple daily dosing. However, this information is based on non‐randomized studies, which used higher serum lithium levels than are currently used. In fact, the incidence of polyuria may be lower at currently used lithium levels, and the benefits of a single daily dose regimen on urine volume at these levels have not been assessed. We conducted a prospective randomized study to test the hypothesis that switching patients from multiple daily dose lithium to single daily dose lithium would significantly lower urine volume. Twenty‐four patients previously stabilized on multiple daily dosing were randomly allocated to either single or multiple daily dose lithium. Twenty‐four‐hour urine volume, serum creatinine, creatinine clearance and serum lithium were measured at study entry and completion. Switching to single daily dose lithium did not significantly reduce the 24‐h urine volume.