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Study of chronic schizophrenics using 31 P magnetic resonance chemical shift imaging
Author(s) -
Fujimoto T.,
Nakano T.,
Takano T.,
Hokazono Y.,
Asakura T.,
Tsuji T.
Publication year - 1992
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1992.tb03297.x
Subject(s) - phosphomonoesters , phosphocreatine , basal ganglia , chemistry , basal (medicine) , endocrinology , medicine , beta (programming language) , alpha (finance) , nuclear magnetic resonance , in vivo , magnetic resonance imaging , energy metabolism , central nervous system , biology , physics , radiology , insulin , construct validity , nursing , microbiology and biotechnology , computer science , patient satisfaction , programming language
Phosphorus‐31 chemical shift imaging showed regional abnormalities of in vivo 31 P NMR spectra in the brains of chronic schizophrenic patients. In the left temporal region, the level of % phosphodiesters (PDE) was increased and the level of %γαβ‐ATP (obtained by summation of γ‐ATP, α‐ATP, and β‐ATP) was decreased. In the basal ganglia, the levels of % PDE were decreased and the level of % phosphomonoesters was increased. The levels of %γαβ‐ATP were increased in the right basal ganglia. The level of % phosphocreatine was decreased in the frontoparietal region. These findings may represent different patterns of dysfunction of membrane phospholipid bilayers and high‐energy phosphate metabolism in the specific cerebral regions.