Premium
Aldosterone responses to angiotensin II in anorexia nervosa
Author(s) -
Mizuno O.,
Tamai H.,
Fujita M.,
Kobayashi N.,
Komaki G.,
Matsubayashi S.,
Nakagawa T.
Publication year - 1992
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1992.tb03296.x
Subject(s) - medicine , aldosterone , endocrinology , anorexia nervosa , supine position , angiotensin ii , mineralocorticoid , renin–angiotensin system , hydrocortisone , blood pressure , eating disorders , psychiatry
Patients with anorexia nervosa (AN) tend to have renin‐angiotensin‐aldosterone (RAA) abnormalities caused by abnormal behaviors such as strict dieting, fasting, vigorous exercise, self‐induced vomiting and abuse of laxatives and/or diuretics. Adrenal responsiveness to angiotensin II (A II) was studied in 13 AN patients before and after therapy and in 6 normal sex‐ and age‐matched controls: adrenal responses to postural change (1 h of walking following 1 h in a supine position) and to exogenous A II injection (A II: 10 ng/kg/min intravenous infusion for 30 min). The 24‐h urine sodium concentration was significantly lower in AN patients before therapy than after therapy. Plasma aldosterone secretory response to A II was significantly higher in AN patients before therapy in both postural change and exogenous A II injection tests compared with after therapy response and that of controls. On the other hand, there was no significant difference in adrenal response to postural change or to exogenous A II between AN patients after therapy and controls. In conclusion, increased A II sensitivity caused by chronic sodium deficiency in AN patients normalized over time as the patients recovered.