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Debrisoquine oxidation phenotype and neuroleptic‐induced dystonic reactions
Author(s) -
Spina E.,
Sturiale V.,
Valvo S.,
Ancione M.,
Rosa A. E. Di,
Meduri M.,
Caputi A. P.
Publication year - 1992
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1992.tb03281.x
Subject(s) - debrisoquine , dystonia , medicine , hydroxylation , psychiatry , cyp2d6 , chemistry , biochemistry , metabolism , cytochrome p450 , enzyme
To evaluate the role of defective drug oxidation as a predisposing factor for neuroleptic‐induced dystonic reactions, 26 patients who developed the reaction and 53 with no history of dystonia were phenotyped by the debrisoquine hydroxylation test. The percentage of poor debrisoquine metabolizers was similar in patients with dystonic reactions (11.5%) and in the control group (9.4%). These results suggest that there is no association between the individual's drug oxidative status and the occurrence of neuroleptic‐induced dystonia.