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Platelet 3 H‐imipramine binding during recovery from depression
Author(s) -
Ellis P. M.,
Beeston R.,
McIntosh C. J.,
Salmond C. E.,
Cooke R. R.
Publication year - 1992
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1992.tb03237.x
Subject(s) - imipramine , depression (economics) , platelet , medicine , major depressive episode , endocrinology , psychology , psychiatry , cognition , pathology , alternative medicine , economics , macroeconomics
Decreased binding of tritiated imipramine to platelets has been considered to be a potential biological marker of depression. However, it has been unclear how binding values alter during treatment and recovery. This study investigated imipramine binding parameters and depressive symptoms in 25 patients suffering from major depression at entry to the study and 1, 3 and 6 months later. Although the initial B max values were significantly lower in the depressed patients than in healthy subjects, it was not possible to establish a clear relationship between recovery from depression and B max . The power of this study to detect an effect of at least 10% of the variance in B max due to factors related to recovery from depression was 0.78.