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Therapeutic sleep deprivation in a depressed patient: prolongation of response with concurrent thyroxine
Author(s) -
Southmayd S. E.,
Kasurak P.,
MacDonald B.,
Waldron J.
Publication year - 1992
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1992.tb03232.x
Subject(s) - medicine , antidepressant , sleep deprivation , depression (economics) , sleep (system call) , circadian rhythm , endocrinology , psychology , computer science , hippocampus , economics , macroeconomics , operating system
A 53‐year‐old woman with major depression was studied throughout 7 trials of therapeutic sleep deprivation (SD). Under conditions where the patients was either medication‐free or receiving antidepressant therapy, improvement with SD was followed by full relapse on returning to sleep. Four SD sessions conducted while the patient was receiving thyroxine each resulted in remission, sustained for several days. These results suggest that the beneficial effects of SD may be mediated by thyroid hormones, or associated activity in the hypothalamic‐pituitary‐adrenal axis.