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Treatment resistance of depression after head injury: a preliminary study of amitriptyline response
Author(s) -
Dinan T. G.,
Mobayed M.
Publication year - 1992
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1992.tb01472.x
Subject(s) - amitriptyline , depression (economics) , tricyclic , head injury , medicine , treatment resistant depression , tricyclic antidepressant , anesthesia , psychology , psychiatry , antidepressant , pharmacology , economics , macroeconomics , hippocampus
Thirteen patients with depression following minor head injury were matched with 13 functional depressives. Both groups were indistinguishable psychopathologically. Five of the functional group had a family history of affective disorder and none of the head‐injury group had such a history. Both groups were treated with amitriptyline, beginning with 100 mg daily, increasing to a maximum of 250 mg/d. There were significant differences in response between the 2 groups, with only 4 of the head‐injury patients improving. Our preliminary results suggest that this condition is relatively resistant to tricyclic therapy.