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Kidney functioning during lithium treatment: a prospective study of patients treated with lithium for up to ten years
Author(s) -
Povlsen U. J.,
Hetmar O.,
Ladefoged J.,
Bolwig T. G.
Publication year - 1992
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1992.tb01442.x
Subject(s) - polyuria , lithium (medication) , medicine , prospective cohort study , renal function , cohort , lithium carbonate , urology , urine , cohort study , endocrinology , chemistry , ion , organic chemistry , ionic bonding , diabetes mellitus
A cohort of 53 patients with affective disorders who originally carried through renal functional tests before start of prophylactic lithium treatment were followed up prospectively after an average period of 8.5 years (range 7–10 years). Ten patients who had continued lithium treatment were re‐examined. In this subgroup, the glomerular function was unaffected by the treatment, whereas the average urine volume increased during lithium treatment (NS). Polyuria and low renal concentrating abilities were also found before start of treatment and these findings underline the importance of access to renal baseline information prior to lithium treatment.