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Double‐blind comparative multicentre study of fluvoxamine and mianserin in the treatment of major depressive episode in elderly people
Author(s) -
Phanjoo A. L.,
Wonnacott S.,
Hodgson A.
Publication year - 1991
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1991.tb05579.x
Subject(s) - fluvoxamine , mianserin , nausea , depression (economics) , vomiting , psychology , medicine , major depressive episode , depressive symptoms , anesthesia , psychiatry , antidepressant , anxiety , fluoxetine , serotonin , mood , receptor , macroeconomics , economics
This is a multicentre double‐blind study of fluvoxamine versus mianserin in the treatment of major depressive episode in patients over 65 years of age. Fifty‐seven patients received either fluvoxamine (100‐200 mg daily) or mianserin (40‐80 mg daily). There was no statistically significant difference in improvement between the 2 treatment groups as measured by the Montgomery‐Ǎsberg Depression Rating Scale. Eleven patients (7 in the fluvoxarnine group and 4 in the mianserin group) discontinued treatment because of intolerance. No statistically significant differences were seen in biological parameters with either drug. Both drugs improved the symptoms of depression though the overall response rate was not outstanding. The side effects profile for the fluvoxamine was contrary to previous studies in that frequent nausea and vomiting were not seen.