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Immune system‐associated antigens on the surface of peripheral blood lymphocytes in patients with Alzheimer's disease
Author(s) -
Ikeda T.,
Yamamoto K.,
Takahashi K.,
Yamada M.
Publication year - 1991
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1991.tb05573.x
Subject(s) - immune system , cd8 , antigen , immunology , cd4 cd8 ratio , flow cytometry , t lymphocyte , cd3 , peripheral , medicine , biology , lymphocyte subsets
We investigated the immune‐associated antigens of peripheral lymphocytes from 13 patients with Alzheimer's disease (AD) and 13 age‐matched healthy control subjects using two‐color analysis with flow cytometry. Four ratios of immune‐related antigens, T/B lymphocytes, CD4/CD8, CD4/CD45R and CD4/HLA‐DR. were compared for the AD and control groups. The T/B and CD4/CD8 ratios did not differ between the groups, the ratio of CD4 + CD45R + subset in the AD group was lower than the ratio in the control group, and the ratios of CD4 + CD45R − and. CD4 + HLA‐DR + subsets in the AD group were significantly higher. Further, in the AD group, the CD4 + CD45R + /CD4 + ratio was lower and the CD4 + CD45R − /CD4 + ratio was higher than in the control group.