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Cerebrospinal fluid acetylcholinesterase in patients with dementia associated with schizophrenia or chronic alcoholism
Author(s) -
Koponen H.,
Riekkinen P. J.
Publication year - 1991
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1991.tb05572.x
Subject(s) - acetylcholinesterase , cerebrospinal fluid , dementia , aché , schizophrenia (object oriented programming) , medicine , psychosis , psychiatry , psychology , chronic alcoholism , degenerative disease , central nervous system disease , disease , enzyme , chemistry , biochemistry
Cerebrospinal fluid (CSF) acetylcholinesterase (AChE) was determined for 11 chronic schizophrenic patients with dementia, 9 patients with dementia associated with alcoholism and 8 age‐equivalent control subjects. The AChE levels in both patient groups were unrelated to the degree of cognitive decline and they were in the same range as in the control group. In schizophrenic patients no relationship was found between CSF AChE and the severity of psychotic symptoms. Our results suggest that dementia may occur in these patient groups without CSF AChE involvement.