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Cerebrospinal fluid variables among alcoholics lack seasonal variation
Author(s) -
Roy A.,
Adinoff B.,
DeJong J.,
Linnoila M.
Publication year - 1991
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1991.tb03199.x
Subject(s) - cerebrospinal fluid , serotonergic , monoamine neurotransmitter , serotonin , metabolite , lumbar puncture , 5 hydroxyindoleacetic acid , medicine , physiology , endocrinology , psychology , receptor
Seasonal influences on indices of serotonergic function, including cerebrospinal fluid (CSF) concentrations of the serotonin metabolite 5‐hydroxyindoleacetic acid (5‐HIAA), have been reported in psychiatric patients and healthy volunteers. We examined seasonal differences in CSF concentrations of 5‐HIAA among 135 alcoholics admitted to a research ward who had a lumbar puncture. No significant seasonal differences were found for either CSF concentrations of 5‐HIAA or CSF concentrations of other monoamine metabolites or peptides. The possible explanations for these negative findings are discussed.