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Moclobemide in depression: a randomized, multicentre trial against isocarboxazide and clomipramine emphasizing atypical depression
Author(s) -
Larsen J. K.,
Gjerris A.,
Holm P.,
Andersen J.,
Bille A.,
Christensen E. M.,
Høyer E.,
Jensen H.,
Mejlhede A.,
Langagergaard A.,
Laursen A. L.,
Nilakantan B.,
Olafsson K.,
Severin B.,
Rafaelsen O. J.
Publication year - 1991
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1991.tb03196.x
Subject(s) - moclobemide , clomipramine , anticholinergic , depression (economics) , medicine , randomized controlled trial , psychology , anesthesia , psychiatry , antidepressant , anxiety , macroeconomics , economics
Moclobemide was compared with isocarboxazide and clomipramine in patients with depression. A total of 167 outpatients were allocated to daily treatment with 300 mg moclobemide, 30 mg isocarboxazide or 150 mg clomipramine for 6 weeks. Moclobemide was slightly inferior to clomipramine, whereas isocarboxazide had an intermediate position. There was no interaction between treatment and atypical or nonatypical depression. Anticholinergic symptoms and orthostatic hypotension were most pronounced in the clomipramine group.