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Moclobemide versus clomipramine in the treatment of depression: a double‐blind multicentre study in Belgium
Author(s) -
Dierick M.,
Cattiez P.,
Franck G.,
Burton P.,
Defleur J.,
Hermans W.,
Roelandts A.,
Wolfram C.,
Berger M.,
Hellstern K.,
Ward J.
Publication year - 1990
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1990.tb05328.x
Subject(s) - moclobemide , clomipramine , depression (economics) , endogenous depression , psychology , medicine , randomized controlled trial , anesthesia , antidepressant , endogeny , hippocampus , economics , macroeconomics
Moclobemide and clomipramine were compared for efficacy, tolerance and safety in 63 mixed endogenous and nonendogenous depressed patients. Treatment was given for at least 4 weeks in a double‐blind, randomized, parallel‐group design. The mean Hamilton Rating Scale for Depression score decreased gradually during treatment with no differences between groups. Two patients on clomipramine and none on moclobemide were withdrawn for lack of efficacy, and poor tolerance caused 3 patients on moclobemide and 7 on clomipramine to stop treatment prematurely. Patients with endogenous depression responded better to clomipramine, whereas nonendogenous disorders did better on moclobemide. Adverse events were more frequent in the clomipramine group and more of these were severe or very severe than for moclobemide. Thus, although no significant difference in efficacy was seen, moclobemide appeared to be tolerated better than clomipramine. The numbers were small, however, and many patients received concomitant medication, and the results are therefore difficult to interpret.