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Pharmacokinetics of antipsychotic drugs in man
Author(s) -
Dahl S. G.
Publication year - 1990
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1990.tb05283.x
Subject(s) - pharmacokinetics , antipsychotic , medicine , pharmacology , antipsychotic drug , schizophrenia (object oriented programming) , psychiatry
Variability in the outcome of treatment with antipsychotic drugs may be due to differences in compliance and to variations in pharmacokinetics and concentration‐response relationships at the receptor level. Among the various chemical classes of neuroleptics, the butyrophenones, the phenothiazines, and the thioxanthenes have similar pharmacokinetics, and show larger inter‐individual variations in plasma drug levels after oral than after intramuscular doses. Compared to the “classical” neuroleptics, the more water‐soluble benzamide derivatives have significantly shorter elimination half‐lives, and show smaller inter‐patient variations in plasma level: dose