Premium
Vitamin B 12 levels in serum and cerebrospinal fluid of people with Alzheimer's disease
Author(s) -
Ikeda T.,
Furukawa Y.,
Mashimoto S.,
Takahashi K.,
Yamada M.
Publication year - 1990
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1990.tb01395.x
Subject(s) - cerebrospinal fluid , medicine , dementia , senile dementia , alzheimer's disease , endocrinology , group b , degenerative disease , group a , disease , gastroenterology
Vitamin B 12 levels in the serum and the cerebrospinal fluid (CSF) were compared between patients with Alzheimer's disease (AD) and senile dementia of Alzheimer's type (SDAT) (AD group) and patients with multi‐infarct dementia (MID group). The B 12 levels in the serum and the CSF were 742 ± 359 pg/ml and 28 ± 7 pg/ml (mean ± SD), respectively, in the AD group, and 962 ± 254 pg/ml and 50 ± 26 pg/ml, respectively, in the MID group. CSF B 12 levels were significantly lower in the AD group than in the MID group, whereas the serum levels were not different. At the same time, the serum levels of almost all patients were within the normal range, whereas the CSF levels were 25 pg/ml or lower in 10 of 12 AD patients. Therefore, this low level in the CSF is considered to be a characteristic finding in the AD group.