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Differential drug response of panic and agoraphobic avoidance in a case of panic disorder
Author(s) -
Klein E.,
Metz L.
Publication year - 1990
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1990.tb01362.x
Subject(s) - agoraphobia , clomipramine , phenelzine , panic , panic disorder , psychology , avoidance behaviour , psychiatry , alprazolam , clinical psychology , psychotherapist , anxiety , biochemistry , chemistry , monoamine oxidase , enzyme
A case is presented of a patient with severe panic disorder and agoraphobia in whom initial treatment with clomipramine resulted in complete elimination of panic attacks, with no improvement in agoraphobic avoidance. The addition of phenelzine to the pre‐existing clomipramine treatment resulted in rapid and complete disappearance of the agoraphobic avoidance. The possible implications of this case for our understanding of the neurobiological relationship between panic attacks and agoraphobia are discussed.