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A cerebrospinal fluid study of the pathophysiology of panic disorder associated with alcoholism
Author(s) -
George D. T.,
Adinoff B.,
Ravitz B.,
Nutt D. J.,
Jong J. De,
Berrettini W.,
Mefford I. N.,
Costa E.,
Linnoila M.
Publication year - 1990
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1990.tb01345.x
Subject(s) - panic disorder , cerebrospinal fluid , panic , neurochemistry , pathophysiology , psychology , population , medicine , psychiatry , neurology , anxiety , environmental health
In order to investigate the neurochemistry of panic disorder in alcoholics, we measured various cerebrospinal fluid (CSF) parameters in subjects with both conditions and compared them with an age‐ and sex‐matched population of alcoholics and normal controls. When height, age and weight were covaried, subjects with panic disorder had higher levels of B‐endorphin in CSF. There were no differences in other CSF measures between the groups. Alcoholics with panic disorder had higher plasma MHPG concentrations compared with alcoholics without panic disorder but these were not statistically different from controls.