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The psychomotor effects of paroxetine alone and in combination with haloperidol, amylobarbitone, oxazepam, or alcohol
Author(s) -
Cooper S.M.,
Jackson D.,
Loudon J.M.,
McClelland G.R.,
Raptopoulos P.
Publication year - 1989
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1989.tb07174.x
Subject(s) - oxazepam , research centre , library science , medicine , computer science , receptor , benzodiazepine
.Many antidepressants in current use cause an impairment in psychomotor performance, particularly during the first week of pharmacotherapy. Combination with sedative drugs can further impair performance (1). Unlike typical sedative antidepressants, paroxetine does not possess a sedative quantitative EEG drug profile in normal volunteers (2). Four studies were undertaken to examine the effects of coadministration of paroxetine with haloperidol, amylobarbitone, alcohol, or oxazepam on psychomotor performance in healthy volunteers.