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Chronic melperone administration does not enhance oral movements in rats
Author(s) -
Gunne L. M.,
Johansson P.
Publication year - 1989
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1989.tb06436.x
Subject(s) - haloperidol , tardive dyskinesia , dyskinesia , oral administration , medicine , pharmacology , anesthesia , psychology , schizophrenia (object oriented programming) , psychiatry , dopamine , disease , parkinson's disease
Melperone and haloperidol were compared in a rat model for tardive dyskinesia. Drugs were given chronically for 12 months with the drinking water and the frequency of oral movements was measured at monthly intervals. Haloperidol (0.2 and 0.4 mg/kg/d) produced an increase in vacuous chewing movements, whereas melperone (2.4, 5.1 and 11.0 mg/kg/d) did not differ from untreated controls.