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Melperone and clozapine: neuroendocrine effects of atypical neuroleptic drugs
Author(s) -
Meltzer Herbert Y.,
Koenig James I.,
Nash J. Frank,
Gudelsky Gary A.
Publication year - 1989
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1989.tb06432.x
Subject(s) - clozapine , antipsychotic , schizophrenia (object oriented programming) , atypical antipsychotic , corticosterone , medicine , endocrinology , pharmacology , psychology , neuroscience , psychiatry , hormone
The effects of atypical neuroleptics within the neuroendocrine axis of rodents can be distinguished from those of typical neuroleptics by the production of: 1) a shortlived increase in serum PRL concentrations, 2) an acute increase in the activity of TIDA neurons, and 3) a marked increase in serum corticosterone concentrations. It is of interest to specculate that the pharmacological properties of atypical neuroleptics which mediate the unique neuroendocrine responses are of relevance to an understanding of the mechanisms which underlie the clinical profile of these antipsychotic agents.