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Approaches for finding new types of antipsychotic compounds
Author(s) -
Sedvall Göran
Publication year - 1989
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1989.tb06431.x
Subject(s) - dopamine , dopaminergic , antipsychotic , neuroscience , serotonergic , psychosis , dopamine hypothesis of schizophrenia , schizophrenia (object oriented programming) , dopamine receptor , psychology , efferent , dopamine receptor d2 , typical antipsychotic , medicine , psychiatry , receptor , afferent , atypical antipsychotic , serotonin
There is strong evidence that pharmacological interaction with central dopamine transmission at several levels may induce antipsychotic effects in psychiatric patients. All the pharmacological principles interacting with other systems have so far not been established with regard to antipsychotic potential. Besides the dopamine system pharmacological manipulation of central serotonergic, gabaergic and noradrenergic mechanisms may also be of therapeutic value in schizophrenia. The interaction of peptidergic mechanisms and central dopaminergic mechanisms is another avenue for further exploration regarding to pathophysiology of psychosis and its treatment. Elucidation of the heterogeneity and molecular structure of central dopamine receptors seems the most rational approach for creating new dimensions for further development of drug design for pharmacotherapy of psychosis. The detailed mapping of afferent and efferent systems coupled to central dopamine neurons is also an approach that may give guide‐lines for finding new types of antipsychotic drugs.