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Pharmacological data of the atypical neuroleptic compound melperone (Buronilr̀)
Author(s) -
Christensson E. G.
Publication year - 1989
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1989.tb06430.x
Subject(s) - neurotransmission , pharmacology , antipsychotic , psychology , atypical antipsychotic , animal studies , neuroscience , medicine , receptor , schizophrenia (object oriented programming) , psychiatry
Based on the non‐cataleptic properties, the weak affinity for D 2 receptors and the inability to induce DA receptor supersensitivity after both acute and repeated administration, melperone may be characterized as an atypical neuroleptic drug. This indicates a weak effect of melperone on striatal DA neurotransmission. On the other hand melperone is potent in blocking amphetamine induced locomotion, exploratory behaviour, L‐Dopa induced jumping and aggression suggesting a limbic mode of action. The effect on limbic Da neurotransmission together with an antiadrenergic and 5‐HT modulating action may explain the antipsychotic effect and the low incidence of extrapyramidal side effects observed during treatment with melperone.