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Lack of seasonal variation in pediatric lumbar cerebrospinal fluid neurotransmitter metabolite concentrations
Author(s) -
Swedo S. E.,
Kruesi M. J. P.,
Leonard H. L.,
Hamburger S. D.,
Cheslow D. L,
Stipetic M.,
Potter W. Z.
Publication year - 1989
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1989.tb03038.x
Subject(s) - homovanillic acid , cerebrospinal fluid , medicine , metabolite , neurotransmitter , endocrinology , 5 hydroxyindoleacetic acid , monoamine neurotransmitter , psychology , conduct disorder , physiology , serotonin , psychiatry , central nervous system , receptor
— Seasonal variation of cerebrospinal fluid (CSF) monoamines, particularly 5‐hydroxyindoleacetic acid (5‐HIAA) and homovanillic acid (HVA) has been reported for psychiatrically ill and normal adults. Circannual variability was examined for a group of 72 children (mean age = 159.4 ± 40.3 (SD), range 77–238 months), with a primary diagnosis of obsessive‐compulsive disorder (OCD) or disruptive behavior disorder (DBD) (attention deficit disorder, oppositional disorder and/or conduct disorder), from whom CSF had been obtained systematically. There were no seasonal differences in mean concentrations of 3‐methoxy‐4‐hydroxyphe‐nylglycol (MHPG), HVA, or 5‐HIAA, either for the group as a whole, for the separate diagnostic (OCD vs DBD) categories or for the pre‐pubertal subgroup. Log‐corrected HVA concentrations For the Tanner IV and V subgroup differed by season with summer concentrations less than those of fall (P = 0.06) and winter (P = 0.005). The results suggest that pubertal changes may play a role in any expression of circannual variability.