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Two regimens of lithium prophylaxis and renal function
Author(s) -
Muir A.,
Davidson R.,
Silverstone T.,
Dawnay A.,
Forsling M. L.
Publication year - 1989
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1989.tb03029.x
Subject(s) - lithium (medication) , medicine , renal function , intensive care medicine
— Two regimens of lithium prophylaxis with different pharmacokinetic characteristics were compared under double‐blind conditions in 25 bipolar patients in remission already stabilized on lithium, to determine the relative effects of each regimen on renal function. Once‐daily lithium carbonate (Priadal), which gives a peak lithium plasma level 2–3 h post‐administration with a low level 24 h later, was compared with twice‐daily lithium citrate (Litarex), which maintains a steadier 24 h plasma level. Patients were allocated randomly to one of the 2 regimens. They were seen monthly for clinical ratings over the course of 12 months. A comprehensive battery of renal function tests was undertaken at the start of the trial, between 6–9 months after the start and again after 1 year. No significant differences were observed in clinical outcome, side effects or renal function between the 2 regimens.