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Platelet monoamine oxidase, plasma dopamine β‐hydroxylase activity, dementia and family history of alcoholism in chronic alcoholics
Author(s) -
Lykouras E.,
Markianos M.,
Moussas G.
Publication year - 1989
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1989.tb03010.x
Subject(s) - monoamine oxidase , abstinence , family history , medicine , endocrinology , dopamine , psychology , dementia , monoamine oxidase a , platelet , psychiatry , enzyme , chemistry , biochemistry , disease
— The authors measured platelet monoamine oxidase (MAO) activity and plasma dopamine β‐hydroxylase activity in 36 male chronic alcoholics during a period of non‐abstinence, and in 29 normal controls. The influence of family history, dementia, chronicity of drinking and liver injury on the enzyme activities was also examined by multiple regression analysis. Platelet MAO was significantly lower in the alcoholic group. Both enzyme activities were negatively related to the presence of dementia, while low MAO activity was associated with positive family history (parents, sibs) of alcoholism.