Premium
Serum dopamine‐β‐hydroxylase activity in clinical subtypes of depression
Author(s) -
Sapru M. K.,
Rao B. S. S. R.,
Channabasavanna S. M.
Publication year - 1989
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1989.tb03008.x
Subject(s) - depression (economics) , medicine , dopamine , research diagnostic criteria , psychiatry , psychology , schizophrenia (object oriented programming) , endocrinology , economics , macroeconomics
— Serum dopamine‐β‐hydroxylase (DBH) activity was determined in male adult psychiatric patients ( n ‐ 280) and age‐matched male healthy controls ( n = 100). Patients included in the study had no history of previous or current exposure to psychoactive drugs and were diagnosed according to Research Diagnostic Criteria. A significant decrease in serum DBH activity was noted in patients with psychotic major depressive disorder ( n = 50) as compared with controls. In acute schizophrenics ( n = 100), nonpsychotic major depressives (n = 45) and patients with manic disorder ( n = 85), mean DBH activity did not differ significantly from the control values.