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Urinary excretion of albumin and retinol‐binding protein in lithium‐treated patients
Author(s) -
Jensen H. V.,
Holm J.,
Hemmingsen L.,
Thiesen S.,
Andersen J.
Publication year - 1988
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1988.tb06351.x
Subject(s) - microalbuminuria , albumin , retinol binding protein , endocrinology , lithium (medication) , creatinine , medicine , renal function , excretion , urinary system , catabolism , chemistry , urine , albuminuria , retinol , metabolism , vitamin
Urinary excretion of albumin and retinol‐binding protein was measured by means of sensitive and specific immunochemical methods in a transverse study of 20 lithium‐treated patients and 24 apparently healthy individuals. Albumin creatinine clearance ratios were significantly higher in the lithium‐treated patients, which may indicate glomerular lesions. Microalbuminuria correlated highly to duration of lithium therapy. No significant difference between the retinol‐binding protein creatinine clearance ratios in the two groups could be shown. This suggests that the catabolism of low‐molecular‐mass proteins in the proximal tubules was normal.