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N‐acetylation and serotonergic measures in a group of psychiatric patients
Author(s) -
TräskmanBendz L.,
Stanley M.,
Stanley B.,
Matthews B.,
Brown L.
Publication year - 1988
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1988.tb05196.x
Subject(s) - serotonergic , acetylation , psychiatry , medicine , imipramine , schizophrenia (object oriented programming) , depression (economics) , psychology , serotonin , clinical psychology , genetics , biology , macroeconomics , gene , receptor , alternative medicine , pathology , economics
— Serotonin is N‐acetylated to melatonin. The purpose of this study was to explore the possibility of N‐acetylation of dapsone reflecting serotonergic activity. The ratio of monoacetyldapsone/dapsone (MAD/DDS) in plasma, 5‐HIAA in CSF, and imipramine‐binding to platelets were investigated in a group of psychiatric patients, diagnosed according to the DSM‐III as affective disorders, schizophrenia, and personality disorders. There was no significant correlation between either of the serotonergic estimates and N‐acetylation in the whole patient group or in diagnostic subgroups of patients. Sixty‐four percent of the patients were slow N‐acetylators (MAD/DDS < 0.4), which is a ratio in line with several other studies of psychiatric patients. Among patients with affective disorders, all unipolar patients were slow N‐acetylators, while five out of six bipolar patients were fast N‐acetylators. The N‐acetylation of patients with a history of suicide attempt did not differ from those without. The discrepancy in N‐acetylation between uni‐ and bipolar patients might again address the issue of them representing two different biochemical and genetic disorders.