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Insulin‐like growth factors and somatomedin B in the cerebrospinal fluid of patients with dementia of the Alzheimer type
Author(s) -
Tham A.,
Sparring K.,
Bowen D.,
Wetterberg L.,
Sara V. R.
Publication year - 1988
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1988.tb05193.x
Subject(s) - somatomedin , cerebrospinal fluid , endocrinology , medicine , dementia , alzheimer's disease , insulin , insulin like growth factor , chemistry , growth factor , receptor , biology , disease
— Cerebrospinal fluid levels of radioreceptor assayable insulin‐like growth factors (RRA‐IGFs) and immunoreactive somatomedin B (SMB) (RIA‐B) were determined in apparently healthy individuals and in patients with dementia of the Alzheimer type (AD). The CSF levels of RIA‐B and RRA‐IGFs did not alter from the healthy controls. After being acidified, the CSF from the controls and from the presenile ADs were separated over a G‐50 fine Sephardex. The RRA‐IGFs activity eluted in three peaks. The results indicate that the major constituent of CSF RRA in both AD patients and controls is an IGF binding protein. The two minor peaks eluted at approximately 9 K and 6 K, corresponding to the elution possitions of “big” IGF‐2 and IGF‐2.