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Zuclopenthixol acetate in Viscoleo® ‐ a new drug formulation
Author(s) -
Amdisen A.,
Nielsen M.S.,
Dencker S.J.,
Fensbo C.,
Ahlfors U.G.,
Gravem A.,
Baastrup P.C.,
Bjerkenstedt L.,
Gunby B.,
Wiesel FA.,
Lindholm H.,
Rafaelsen O.J.,
FredslundAndersen K.,
Thomsen N.J.,
Rosell I.,
Pakarinen P.,
Harma P.,
Amthor K.F.,
Kastberg S.,
Abelskov J.
Publication year - 1987
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1987.tb02759.x
Subject(s) - medicine , sedation , anesthesia , intramuscular injection , extrapyramidal symptoms , surgery , schizophrenia (object oriented programming) , antipsychotic , psychiatry
— Eighty‐three acutely disturbed, psychotic patients were included in an open multicentre study. The aim of the study was to evaluate the clinical effect of zuclopenthixol acetate in Viscoleo® (CPT‐A). Each patient received from one to four intramuscular injections of CPT‐A during the 6‐day study period. The duration of action after one injection was between 2 and 3 days and doses from 50 mg to 150 mg were sufficient for most patients. Treatment with CPT‐A caused a pronounced and rapid reduction of the psychotic symptoms. At the end of the 6‐day test period the mean total score on BPRS in acute non‐manic and exacerbated chronic patients was reduced by more than 50 per cent. In acute manic patients the mean total score on BRMS was reduced by 57 per cent already 1 day after injection. Rapidly after the injection of CPT‐A a useful short‐acting sedation can be expected, but the risk for oversedation even after a second injection is low. The frequency of unwanted effects, including extrapyramidal reactions, was low and the severity of symptoms was most often mild. With a rapid onset of action, a duration of effect of 2 to 3 days, and few and mild side effects, CPT‐A offers advantages over the neuroleptic preparations conventionally used in the initial treatment of acutely disturbed, psychotic patients.