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Is there a relationship between response to total sleep deprivation and efficacy of clomipramine treatment in depressed patients?
Author(s) -
Höchli D.,
Riemann D.,
Zulley J.,
Berger M.
Publication year - 1986
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1986.tb10605.x
Subject(s) - clomipramine , tricyclic , sleep deprivation , depression (economics) , psychology , major depressive disorder , treatment modality , tricyclic antidepressant , privation , depressive symptoms , psychiatry , medicine , clinical psychology , antidepressant , pharmacology , anxiety , cognition , economics , macroeconomics
— Total sleep deprivation (TSD) and tricyclic medication are successful treatment modalities for patients with a major depressive disorder. Recent studies have suggested a positive relationship between TSD response and succeeding tricyclic treatment, even on a very specific level, thus supporting the assumption of two distinct biochemical subtypes of depression. The present study tested this hypothesis by treating 10 inpatients with a major depressive disorder first with TSD and succeedingly with clomipramine. Contrary to expectation, a negative relationship between clinical response to the two treatment modalities was found.